Brainstorm discusses Science and Wannabe Science
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How science should work...

I have a feeling that I have been mostly a critic of various pseudo-scientific conclusions out there, so I decided to report - for a change - on something positive, about how science should work.

Recently, European Medicines Agency (EMA) updated storage conditions for BioNTech/Pfizer’s COVID-19 vaccine. The previous, approved storage period of the unopened thawed vial at 2-8°C (i.e. in a normal fridge after taking out of deep-freeze conditions) was five days, and now, the new storage date is up-to 31 days (see below). Considering this is so-called microemulsion-system vaccine - which normally has a stability issues on higher temperatures or at least, the long-term stability is hard to achieve - this is a good news. Why? Well, it provides more options for delivery, re-distribution, and storage once it reaches it's destination. For example, if there was a clinic that had issues providing an adequate storage (-80C), now that same clinic can store the vaccines up-to-31 days at 2-8C, which provides them sufficient time to perform vaccinations from the day of delivery - a whole month.

Now, how is possible that now we have 31 day while before we had only 5 days? Well, simply, before, manufacturer had only sufficient evidence of stability for those 5 days, so EMA acted accordingly - despite what everyone "ideally" wanted, and that "ideally" is a vaccine with the longer stability. (If anyone is curious why did take manufacturer so long, hit me in the comments.) Now, the old evidence is updated with new data, and so are the stability conclusions and recommendations: from 5 to 31 days.

And that is how science should work. Despite "the best wishes", we should stick with available evidence and update conclusions when new evidence is available. (Do not confuse this with now-already notorious Fauci-U-turns mostly based on no or dubious evidence).

Simply, evidence gets updated, conclusions get updated.

Of late, I find it remarkably important to explain people that there is nothing wrong with a scientist who changes his/her stance on particular issue in the light of new evidence. This is how science should work. However, I have no excuses for "science followers" who reject to apply this scientific principle - even when advised by CDC to update their "conclusions" 😉

https://www.ema.europa.eu/en/news/more-flexible-storage-conditions-biontechpfizers-covid-19-vaccine

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